Communications Biology (Aug 2021)

Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions

  • Vladislav A. Lushpa,
  • Marina V. Goncharuk,
  • Cong Lin,
  • Arthur O. Zalevsky,
  • Irina A. Talyzina,
  • Aleksandra P. Luginina,
  • Daniil D. Vakhrameev,
  • Mikhail B. Shevtsov,
  • Sergey A. Goncharuk,
  • Alexander S. Arseniev,
  • Valentin I. Borshchevskiy,
  • Xiaohui Wang,
  • Konstantin S. Mineev

DOI
https://doi.org/10.1038/s42003-021-02532-0
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 12

Abstract

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Lushpa et al report the structure and dynamics of the TLR1 toll-interleukin like (TIR) cytoplasmic domain in both crystal and solution. They demonstrate that the TLR1 TIR domain is capable of specific binding of Zn with nanomolar affinity, which appears to be critical for receptor activation, and provide potential structures TLR1-TIR/Zn complex based on in silico data.