New therapeutic agents for metastatic colorectal cancer: literature review

Abstract

This article provides an overview of drugs for metastatic colorectal cancer that are currently being evaluated in clinical trials. We discuss possible drug combinations and outlooks of their use in different lines of therapy. In addition to VEGF and EGFR inhibitors, we describe the molecules with fundamentally new mechanisms of action that can significantly expand the list of anticancer agents and increase the number of possible lines of therapy.

Keywords

• colorectal cancer
• chemotherapy
• targeted drugs
• egfr inhibitors
• vegf inhibitors