Direct Dehydrative Glycosylation Catalyzed by Diphenylammonium Triflate

Abstract

Methods for direct dehydrative glycosylations of carbohydrate hemiacetals catalyzed by diphenylammonium triflate under microwave irradiation are described. Both armed and disarmed glycosyl-C1-hemiacetal donors were efficiently glycosylated in moderate to excellent yields without the need for any drying agents and stoichiometric additives. This method has been successfully applied to a solid-phase glycosylation.

Keywords

• carbohydrates
• dehydration
• glycosylation
• homogeneous catalysis microwave chemistry