CyTOF Profiling of Zika and Dengue Virus-Infected Human Peripheral Blood Mononuclear Cells Identifies Phenotypic Signatures of Monotype Subsets and Upregulation of the Interferon-Inducible Protein CD169

Rafael Fenutria; Kevin Maringer; Uma Potla; Dabeiba Bernal-Rubio; Matthew J. Evans; Eva Harris; Adeeb H. Rahman; Ana Fernandez-Sesma; Irene Ramos

doi:10.1128/mSphere.00505-21

mSphere (Jun 2021)

CyTOF Profiling of Zika and Dengue Virus-Infected Human Peripheral Blood Mononuclear Cells Identifies Phenotypic Signatures of Monotype Subsets and Upregulation of the Interferon-Inducible Protein CD169

Rafael Fenutria,
Kevin Maringer,
Uma Potla,
Dabeiba Bernal-Rubio,
Matthew J. Evans,
Eva Harris,
Adeeb H. Rahman,
Ana Fernandez-Sesma,
Irene Ramos

Affiliations

Rafael Fenutria: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Kevin Maringer: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Uma Potla: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Dabeiba Bernal-Rubio: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Matthew J. Evans: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Eva Harris: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, USA
Adeeb H. Rahman: Human Immune Monitoring Center, Icahn School of Medicine at Mt. Sinai, New York, New York, USA
Ana Fernandez-Sesma: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Irene Ramos: ORCiD; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

DOI: https://doi.org/10.1128/mSphere.00505-21
Journal volume & issue: Vol. 6, no. 3

Abstract

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Zika and dengue viruses are emergent arboviruses of great public health impact. Both viruses are responsible for important diseases, yet there is currently no vaccine or specific treatment available.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal