Non-canonical reader modules of BAZ1A promote recovery from DNA damage

Mariano Oppikofer; Meredith Sagolla; Benjamin Haley; Hui-Min Zhang; Sarah K. Kummerfeld; Jawahar Sudhamsu; E. Megan Flynn; Tianyi Bai; Jennifer Zhang; Claudio Ciferri; Andrea G. Cochran

doi:10.1038/s41467-017-00866-0

Nature Communications (Oct 2017)

Non-canonical reader modules of BAZ1A promote recovery from DNA damage

Mariano Oppikofer,
Meredith Sagolla,
Benjamin Haley,
Hui-Min Zhang,
Sarah K. Kummerfeld,
Jawahar Sudhamsu,
E. Megan Flynn,
Tianyi Bai,
Jennifer Zhang,
Claudio Ciferri,
Andrea G. Cochran

Affiliations

Mariano Oppikofer: Department of Early Discovery Biochemistry, Genentech, Inc.
Meredith Sagolla: Center for Advanced Light Microscopy, Genentech, Inc.
Benjamin Haley: Department of Molecular Biology, Genentech, Inc.
Hui-Min Zhang: Protein Analytical Chemistry, Genentech, Inc.
Sarah K. Kummerfeld: Department of Bioinformatics and Computational Biology, Genentech, Inc.
Jawahar Sudhamsu: Department of Structural Biology, Genentech, Inc.
E. Megan Flynn: Department of Early Discovery Biochemistry, Genentech, Inc.
Tianyi Bai: Department of Structural Biology, Genentech, Inc.
Jennifer Zhang: Protein Analytical Chemistry, Genentech, Inc.
Claudio Ciferri: Department of Structural Biology, Genentech, Inc.
Andrea G. Cochran: Department of Early Discovery Biochemistry, Genentech, Inc.

DOI: https://doi.org/10.1038/s41467-017-00866-0
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

ISWI chromatin remodelers regulate DNA accessibility and have been implicated in DNA damage repair. Here, the authors uncover functions, in response to DNA damage, for the bromodomain of the ISWI subunit BAZ1B and for the non-canonical PHD and bromodomain modules of the paralog BAZ1A.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal