Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection

Simon J. L. Petitjean; Wenzhang Chen; Melanie Koehler; Ravikumar Jimmidi; Jinsung Yang; Danahe Mohammed; Blinera Juniku; Megan L. Stanifer; Steeve Boulant; Stéphane P. Vincent; David Alsteens

doi:10.1038/s41467-022-30313-8

Nature Communications (May 2022)

Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection

Simon J. L. Petitjean,
Wenzhang Chen,
Melanie Koehler,
Ravikumar Jimmidi,
Jinsung Yang,
Danahe Mohammed,
Blinera Juniku,
Megan L. Stanifer,
Steeve Boulant,
Stéphane P. Vincent,
David Alsteens

Affiliations

Simon J. L. Petitjean: Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain
Wenzhang Chen: Laboratory of Bio-Organic Chemistry (NARILIS), UNamur
Melanie Koehler: Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain
Ravikumar Jimmidi: Laboratory of Bio-Organic Chemistry (NARILIS), UNamur
Jinsung Yang: Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain
Danahe Mohammed: Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain
Blinera Juniku: Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain
Megan L. Stanifer: Dept. of Infectious Diseases, Medical Faculty, Center for Integrative Infectious Diseases Research (CIID), University of Heidelberg
Steeve Boulant: Dept. of Infectious Diseases, Medical Faculty, Center for Integrative Infectious Diseases Research (CIID), University of Heidelberg
Stéphane P. Vincent: Laboratory of Bio-Organic Chemistry (NARILIS), UNamur
David Alsteens: Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain

DOI: https://doi.org/10.1038/s41467-022-30313-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Cell surface attachment factors, such as glycans, play an important role in viral infection. Here, Petitjean et al. show that SARS-CoV-2 specifically binds to 9-Oacetylated sialic acid and have designed novel inhibitors based on multivalent derivatives.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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