Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs

Marissa R Keever-Keigher; Pan Zhang; Courtni R Bolt; Haley E Rymut; Adrienne M Antonson; Megan P Caputo; Alexandra K Houser; Alvaro G Hernandez; Bruce R Southey; Laurie A Rund; Rodney W Johnson; Sandra L Rodriguez-Zas

doi:10.1093/g3journal/jkab113

G3: Genes, Genomes, Genetics (Apr 2021)

Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs

Marissa R Keever-Keigher,
Pan Zhang,
Courtni R Bolt,
Haley E Rymut,
Adrienne M Antonson,
Megan P Caputo,
Alexandra K Houser,
Alvaro G Hernandez,
Bruce R Southey,
Laurie A Rund,
Rodney W Johnson,
Sandra L Rodriguez-Zas

Affiliations

Marissa R Keever-Keigher: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Pan Zhang: Illinois Informatics Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Courtni R Bolt: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Haley E Rymut: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Adrienne M Antonson: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Megan P Caputo: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Alexandra K Houser: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Alvaro G Hernandez: High-Throughput Sequencing and Genotyping Unit, Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Bruce R Southey: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Laurie A Rund: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Rodney W Johnson: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA
Sandra L Rodriguez-Zas: ORCiD; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA

DOI: https://doi.org/10.1093/g3journal/jkab113
Journal volume & issue: Vol. 11, no. 8

Abstract

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AbstractChanges at the molecular level capacitate the plasticity displayed by the brain in response to stress stimuli. Weaning stress can trigger molecular changes that influence the physiology of the offspring. Likewise, maternal immune activation (MIA) during gestation has been associated with behavior disorders and molecular changes in the amygdala of the offspring. This study advances the understanding of the effects of pre- and postnatal stressors in amygdala gene networks. The amygdala transcriptome was profiled on female and male pigs that were either exposed to viral-elicited MIA or not and were weaned or nursed. Overall, 111 genes presented interacting or independent effects of weaning, MIA, or sex (FDR-adjusted P

Published in G3: Genes, Genomes, Genetics

ISSN: 2160-1836 (Online)
Publisher: Oxford University Press
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Genetics
Website: https://academic.oup.com/g3journal

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