Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells

Wei Lu; Jian Xu; Shikui Dong; Guoming Xie; Shuanghui Yang; Xiaoqiao Huangfu; Xiaoxi Li; Yang Zhang; Peng Shen; Zhaowen Yan; Haifeng Liu; Zhenhan Deng; Jinzhong Zhao

doi:10.1002/sctm.18-0132

Stem Cells Translational Medicine (Sep 2019)

Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells

Wei Lu,
Jian Xu,
Shikui Dong,
Guoming Xie,
Shuanghui Yang,
Xiaoqiao Huangfu,
Xiaoxi Li,
Yang Zhang,
Peng Shen,
Zhaowen Yan,
Haifeng Liu,
Zhenhan Deng,
Jinzhong Zhao

Affiliations

Wei Lu: Department of Sports Medicine the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen China
Jian Xu: Department of Sports Medicine the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen China
Shikui Dong: Department of Arthroscopic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China
Guoming Xie: Department of Arthroscopic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China
Shuanghui Yang: Department of Hematology Xiangya Hospital, Central South University Changsha China
Xiaoqiao Huangfu: Department of Arthroscopic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China
Xiaoxi Li: Department of Arthroscopic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China
Yang Zhang: Department of Arthroscopic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China
Peng Shen: Department of Arthroscopic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China
Zhaowen Yan: Department of Pathology Shanghai Jiao Tong University School of Medicine Shanghai China
Haifeng Liu: Department of Sports Medicine the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen China
Zhenhan Deng: Department of Sports Medicine the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen China
Jinzhong Zhao: Department of Arthroscopic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China

DOI: https://doi.org/10.1002/sctm.18-0132
Journal volume & issue: Vol. 8, no. 9
pp. 971 – 982

Abstract

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Abstract As a regular adoptable material for anterior cruciate ligament (ACL) reconstruction, free tendon allograft exhibits unsatisfactory outcomes, such as retarded ligamentization and tendon–bone integration. The application of bone marrow‐derived mesenchymal stem cells (BMSCs), as well as a decellularized free tendon allograft developed by our group, was proven to be effective in improving ACL reconstruction results. This study aimed to investigate the efficacy and feasibility of decellularized allogenic semitendinous tendon (ST) combined with autologous BMSCs used as a substitute to free tendon allograft in a rabbit model. This study finally shows that the decellularized allogenic ST combined with autologous BMSCs could significantly improve ACL reconstruction results compared with allograft. Stem Cells Translational Medicine 2019;8:971&982

Published in Stem Cells Translational Medicine

ISSN: 2157-6564 (Print); 2157-6580 (Online)
Publisher: Oxford University Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Cytology
Website: https://academic.oup.com/stcltm

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Abstract

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