Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-<i>b</i>]Pyridine from a One-Pot Three-Component Reaction

Wei Lin; Cangwei Zhuang; Xiuxiu Hu; Juanjuan Zhang; Juxian Wang

doi:10.3390/molecules24152835

Molecules (Aug 2019)

Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-<i>b</i>]Pyridine from a One-Pot Three-Component Reaction

Wei Lin,
Cangwei Zhuang,
Xiuxiu Hu,
Juanjuan Zhang,
Juxian Wang

Affiliations

Wei Lin: School of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, China
Cangwei Zhuang: School of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, China
Xiuxiu Hu: School of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, China
Juanjuan Zhang: State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China
Juxian Wang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China

DOI: https://doi.org/10.3390/molecules24152835
Journal volume & issue: Vol. 24, no. 15
p. 2835

Abstract

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A concise and efficient approach to synthesizing coumarin-fused pyrazolo[3,4-b]pyridine via silica sulfuric acid (SSA) catalyzed three-component domino reaction under microwave irradiation has been demonstrated. Participation of various alcohols in construction of coumarin derivatives has been described for the first time. Short reaction time, high yields, one-pot procedure, usage of eco-friendly catalyst, and solvent are the key features of this method.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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