Clinical and Translational Radiation Oncology (Mar 2024)

C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect

  • Lucas Schoenauen,
  • François-Xavier Stubbe,
  • Dirk Van Gestel,
  • Sébastien Penninckx,
  • Anne-Catherine Heuskin

Journal volume & issue
Vol. 45
p. 100712

Abstract

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This study explores the effects of UHDR irradiation on Caenorhabditis elegans embryos. UHDR proton and electron beams demonstrate a sparing effect, aligning with literature findings. This highlights C. elegans suitability as a screening model for studying the LET impact on the FLASH effect, reinforcing its potential in radiation research.

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