Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

Xuehui Fan; Tianyi Sun; William Crawford; Xiaoqiu Tan; Xianhong Ou; Derek A. Terrar; Steven N. Ebert; Ming Lei; Ming Lei

doi:10.3389/fphys.2019.00713

Frontiers in Physiology (Jul 2019)

Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

Xuehui Fan,
Tianyi Sun,
William Crawford,
Xiaoqiu Tan,
Xianhong Ou,
Derek A. Terrar,
Steven N. Ebert,
Ming Lei,
Ming Lei

Affiliations

Xuehui Fan: Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China
Tianyi Sun: Department of Pharmacology, University of Oxford, Oxford, United Kingdom
William Crawford: Department of Pharmacology, University of Oxford, Oxford, United Kingdom
Xiaoqiu Tan: Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China
Xianhong Ou: Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China
Derek A. Terrar: Department of Pharmacology, University of Oxford, Oxford, United Kingdom
Steven N. Ebert: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, United States
Ming Lei: Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China
Ming Lei: Department of Pharmacology, University of Oxford, Oxford, United Kingdom

DOI: https://doi.org/10.3389/fphys.2019.00713
Journal volume & issue: Vol. 10

Abstract

Read online

In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca2+ transient properties, and potential role in localized adrenergic signaling are discussed.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

About the journal

Abstract

Keywords