A male-specific doublesex isoform reveals an evolutionary pathway of sexual development via distinct alternative splicing mechanisms

Affiliations

Caihong Han: The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
Qionglin Peng: The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
Xiangbin Su: The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
Limin Xing: The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
Xiaoxiao Ji: The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
Yufeng Pan: The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University

Abstract

An ancestral male-specific doublesex isoform, dsxM2, is identified via intron retention, with a masculinizing function weaker than the modern dsxM