Inherited thrombophilia in pregnancy. Study by questionnaire method in a group of pregnant women

Abstract

Thrombophilia, blood clotting abnormalities that increase the risk of thrombosis, can be inherited (congenital thrombophilia) or acquired during life. We conducted a study using the questionnaire method, which included 38 questions. The questionnaire was posted on social media groups dedicated to patients with thrombophilia in Romania. 99 patients responded to our request to complete the questionnaire, 91 performed tests for the diagnosis of thrombophilia and 85 were diagnosed with thrombophilia (81 diagnosed with inherited thrombophilia, 1 with acquired thrombophilia and 3 with mixed thrombophilia). It was shown that, in our group, the most common inherited thrombophilias are the factor V mutation (FVL) and the MTHFR gene mutation, in over 95% of cases. The results of the study may be a starting point for larger batch studies on the presence of genetic mutations in patients with inherited thrombophilia, to more effectively prevent pregnancy complications.

Keywords

• inherited thrombophilia
• pregnancy complications
• thromboembolic events
• recurrent pregnancy loss
• thromboprophylaxis