Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo

Gonzalo P. Solis; Arghavan Kazemzadeh; Laurence Abrami; Jana Valnohova; Cecilia Alvarez; F. Gisou van der Goot; Vladimir L. Katanaev

doi:10.1038/s41467-022-29685-8

Nature Communications (Apr 2022)

Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo

Gonzalo P. Solis,
Arghavan Kazemzadeh,
Laurence Abrami,
Jana Valnohova,
Cecilia Alvarez,
F. Gisou van der Goot,
Vladimir L. Katanaev

Affiliations

Gonzalo P. Solis: Translational Research Center in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Arghavan Kazemzadeh: Translational Research Center in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Laurence Abrami: Global Health Institute, School of Life Sciences, EPFL
Jana Valnohova: Translational Research Center in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Cecilia Alvarez: Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET). Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba
F. Gisou van der Goot: Global Health Institute, School of Life Sciences, EPFL
Vladimir L. Katanaev: Translational Research Center in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva

DOI: https://doi.org/10.1038/s41467-022-29685-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

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How palmitoylated proteins specifically localize is not fully understood. Here, authors created the SwissKASH assay to visualize S-palmitoylation in cells and uncovered a striking substrate selectivity of acyltransferases at the core of this process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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