AAV2.7m8 is a powerful viral vector for inner ear gene therapy

Kevin Isgrig; Devin S. McDougald; Jianliang Zhu; Hong Jun Wang; Jean Bennett; Wade W. Chien

doi:10.1038/s41467-018-08243-1

Nature Communications (Jan 2019)

AAV2.7m8 is a powerful viral vector for inner ear gene therapy

Kevin Isgrig,
Devin S. McDougald,
Jianliang Zhu,
Hong Jun Wang,
Jean Bennett,
Wade W. Chien

Affiliations

Kevin Isgrig: Neurotology Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health
Devin S. McDougald: Center for Advanced Retinal and Ocular Therapeutics, Perelman School of Medicine, University of Pennsylvania
Jianliang Zhu: Neurotology Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health
Hong Jun Wang: Neurotology Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health
Jean Bennett: Center for Advanced Retinal and Ocular Therapeutics, Perelman School of Medicine, University of Pennsylvania
Wade W. Chien: Neurotology Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health

DOI: https://doi.org/10.1038/s41467-018-08243-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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Adeno-associated virus is used in gene therapy in mouse models of hearing loss. Here the authors compare vectors and find AAV2.7m8 can infect cells in the inner ear with high efficiency.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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