Nature Communications (Jun 2018)
SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
- Rocco Piazza,
- Vera Magistroni,
- Sara Redaelli,
- Mario Mauri,
- Luca Massimino,
- Alessandro Sessa,
- Marco Peronaci,
- Maciej Lalowski,
- Rabah Soliymani,
- Caterina Mezzatesta,
- Alessandra Pirola,
- Federica Banfi,
- Alicia Rubio,
- Delphine Rea,
- Fabio Stagno,
- Emilio Usala,
- Bruno Martino,
- Leonardo Campiotti,
- Michele Merli,
- Francesco Passamonti,
- Francesco Onida,
- Alessandro Morotti,
- Francesca Pavesi,
- Marco Bregni,
- Vania Broccoli,
- Marc Baumann,
- Carlo Gambacorti-Passerini
Affiliations
- Rocco Piazza
- Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospital
- Vera Magistroni
- Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospital
- Sara Redaelli
- Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospital
- Mario Mauri
- Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospital
- Luca Massimino
- Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospital
- Alessandro Sessa
- Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute
- Marco Peronaci
- Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospital
- Maciej Lalowski
- Department of Biochemistry and Developmental Biology, Faculty of Medicine, Meilahti Clinical Proteomics Core Facility, University of Helsinki
- Rabah Soliymani
- Department of Biochemistry and Developmental Biology, Faculty of Medicine, Meilahti Clinical Proteomics Core Facility, University of Helsinki
- Caterina Mezzatesta
- Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospital
- Alessandra Pirola
- Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospital
- Federica Banfi
- Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute
- Alicia Rubio
- Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute
- Delphine Rea
- Service d’Hématologie Adulte, Hôpital Saint-Louis
- Fabio Stagno
- Chair and Hematology Section, Ferrarotto Hospital, AOU Policlinico
- Emilio Usala
- Azienda Brotzu U.O. Ematologia e CTMO, Ospedale Businco
- Bruno Martino
- UO Ematologia Azienda Ospedaliera “BIANCHI MELACRINO MORELLI”
- Leonardo Campiotti
- Dipartimento Medicina Clinica e Sperimentale, Università Insubria
- Michele Merli
- Division of Hematology, University Hospital Ospedale di Circolo e Fondazione Macchi
- Francesco Passamonti
- Hematology, Dipartimento di Medicina Clinica e Sperimentale, University of Varese
- Francesco Onida
- BMT Center - Oncohematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan
- Alessandro Morotti
- Department of Clinical and Biological Sciences, University of Torino
- Francesca Pavesi
- Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute
- Marco Bregni
- Oncology Unit, ASST Valle Olona, Ospedale di Circolo di Busto Arsizio
- Vania Broccoli
- Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute
- Marc Baumann
- Department of Biochemistry and Developmental Biology, Faculty of Medicine, Meilahti Clinical Proteomics Core Facility, University of Helsinki
- Carlo Gambacorti-Passerini
- Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospital
- DOI
- https://doi.org/10.1038/s41467-018-04462-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
SETBP1 variants occur as somatic mutations in several malignancies and as de novo germline mutations in developmental disorders. Here the authors provide evidence that SETBP1 binds to gDNA in AT-rich promoter regions to promote target gene upregulation, indicating SETBP1 functions directly to regulate transcription.
