Journal of Nanobiotechnology (Mar 2022)
PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles
- Yinzhen Fan,
- Zhenli Cheng,
- Lejiao Mao,
- Ge Xu,
- Na Li,
- Mengling Zhang,
- Ping Weng,
- Lijun Zheng,
- Xiaomei Dong,
- Siyao Hu,
- Bin Wang,
- Xia Qin,
- Xuejun Jiang,
- Chengzhi Chen,
- Jun Zhang,
- Zhen Zou
Affiliations
- Yinzhen Fan
- Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University
- Zhenli Cheng
- Department of Cardiovascular Medicine, Children’s Hospital of Chongqing Medical University
- Lejiao Mao
- Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University
- Ge Xu
- Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University
- Na Li
- Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University
- Mengling Zhang
- College of Pharmacy, Chongqing Medical University
- Ping Weng
- College of Pharmacy, Chongqing Medical University
- Lijun Zheng
- Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University
- Xiaomei Dong
- Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University
- Siyao Hu
- College of Pharmacy, Chongqing Medical University
- Bin Wang
- Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University
- Xia Qin
- Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University
- Xuejun Jiang
- Center of Experimental Teaching for Public Health, Experimental Teaching and Management Center, Chongqing Medical University
- Chengzhi Chen
- Department of Occupational and Environmental Health, School of Public Health and Management, Chongqing Medical University
- Jun Zhang
- Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University
- Zhen Zou
- Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University
- DOI
- https://doi.org/10.1186/s12951-022-01338-4
- Journal volume & issue
-
Vol. 20,
no. 1
pp. 1 – 21
Abstract
Highlights 1. CuONPs disturb mitochondrial dynamics and trigger mitophagy in vascular endothelial cells and mouse blood vessel. 2. PINK1/TAX1BP1-mediated mitophagy regulates the removal of excessive ROS and aberrant mitochondria in CuONPs-treated vascular endothelial cells. 3. The mitophagy activator urolithin A attenuates CuONPs-induced vascular endothelial cells death and mice vascular injury.
Keywords
