Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor

Abstract

In the past 10 years, with the increase of investment in clinical nano-gene therapy, there are many trials that have been discontinued due to poor efficacy and serious side effects. Therefore, it is particularly important to design a suitable gene delivery system. In this paper, we introduce the application of liposomes, polymers, and inorganics in gene delivery; also, different modifications with some stimuli-responsive systems can effectively improve the efficiency of gene delivery and reduce cytotoxicity and other side effects. Besides, the co-delivery of chemotherapy drugs with a drug tolerance-related gene or oncogene provides a better theoretical basis for clinical cancer gene therapy. Keywords: gene delivery, nanoparticles, tumor therapy, liposome, polymers, inorganics stimuli response, co-delivery, cellular uptake, nuclear entry