Nature Communications (Jan 2017)
Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
- Amy K. Rines,
- Hsiang-Chun Chang,
- Rongxue Wu,
- Tatsuya Sato,
- Arineh Khechaduri,
- Hidemichi Kouzu,
- Jason Shapiro,
- Meng Shang,
- Michael A. Burke,
- Eltyeb Abdelwahid,
- Xinghang Jiang,
- Chunlei Chen,
- Tenley A. Rawlings,
- Gary D. Lopaschuk,
- Paul T. Schumacker,
- E. Dale Abel,
- Hossein Ardehali
Affiliations
- Amy K. Rines
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Hsiang-Chun Chang
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Rongxue Wu
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Tatsuya Sato
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Arineh Khechaduri
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Hidemichi Kouzu
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Jason Shapiro
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Meng Shang
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Michael A. Burke
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Eltyeb Abdelwahid
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Xinghang Jiang
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Chunlei Chen
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- Tenley A. Rawlings
- Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, University of Utah, School of Medicine
- Gary D. Lopaschuk
- Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta
- Paul T. Schumacker
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- E. Dale Abel
- Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, University of Utah, School of Medicine
- Hossein Ardehali
- Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University
- DOI
- https://doi.org/10.1038/ncomms14095
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maintains cardiac function and energy in mice.
