Olaparib-Induced Purpuric Drug Eruption in a Patient with Castration-Resistant Prostate Cancer

Abstract

Olaparib is recently approved as an anti-tumor agent for several cancers, including castration-resistant prostate cancer, which inhibits poly (adenosine diphosphate-ribose) polymerase, a DNA repair factor. Since olaparib is a newly approved drug, there are few reports of skin disorders that may be triggered by olaparib administration. In this report, we present a case with an olaparib-induced drug eruption presenting multiple purpuras on the patient’s fingers and fingertips. The present case suggests that olaparib might induce purpura as nonallergic drug eruption.

Keywords

• olaparib
• purpura
• drug eruption
• drug reaction
• castration-resistant prostate cancer