Frontiers in Cellular and Infection Microbiology (Sep 2024)
Case report: Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy
- Brieuc Van Nieuwenhuyse,
- Mathilde Balcaen,
- Olga Chatzis,
- Astrid Haenecour,
- Emilien Derycke,
- Thierry Detaille,
- Stéphan Clément de Cléty,
- Cécile Boulanger,
- Cécile Boulanger,
- Cécile Boulanger,
- Leïla Belkhir,
- Leïla Belkhir,
- Jean-Cyr Yombi,
- Julien De Greef,
- Julien De Greef,
- Olivier Cornu,
- Olivier Cornu,
- Pierre-Louis Docquier,
- Pierre-Louis Docquier,
- Audrey Lentini,
- Renaud Menten,
- Hector Rodriguez-Villalobos,
- Hector Rodriguez-Villalobos,
- Alexia Verroken,
- Alexia Verroken,
- Sarah Djebara,
- Maya Merabishvili,
- Johann Griselain,
- Jean-Paul Pirnay,
- Laurent Houtekie,
- Dimitri Van der Linden,
- Dimitri Van der Linden
Affiliations
- Brieuc Van Nieuwenhuyse
- Institute of Experimental and Clinical Research, Pediatric Department (IREC/PEDI), Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Mathilde Balcaen
- Pediatric Intensive Care Unit, Cliniques universitaires Saint-Luc, Université catholique de Louvain – UCLouvain, Brussels, Belgium
- Olga Chatzis
- Pediatric Infectious Diseases, General Pediatrics Department, Cliniques universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Astrid Haenecour
- Pediatric Intensive Care Unit, Cliniques universitaires Saint-Luc, Université catholique de Louvain – UCLouvain, Brussels, Belgium
- Emilien Derycke
- Pediatric Intensive Care Unit, Cliniques universitaires Saint-Luc, Université catholique de Louvain – UCLouvain, Brussels, Belgium
- Thierry Detaille
- Pediatric Intensive Care Unit, Cliniques universitaires Saint-Luc, Université catholique de Louvain – UCLouvain, Brussels, Belgium
- Stéphan Clément de Cléty
- Pediatric Intensive Care Unit, Cliniques universitaires Saint-Luc, Université catholique de Louvain – UCLouvain, Brussels, Belgium
- Cécile Boulanger
- Institute of Experimental and Clinical Research, Pediatric Department (IREC/PEDI), Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Cécile Boulanger
- Genetics of Autoimmune Diseases and Cancer laboratoire (GEDI), de Duve Institute, Université catholique de Louvain – UCLouvain, Brussels, Belgium
- Cécile Boulanger
- Department of Pediatric Hematology and Oncology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Leïla Belkhir
- Division of Internal Medicine and Infectious Disease, Cliniques Universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Leïla Belkhir
- Louvain centre for Toxicology and Applied Pharmacology, Institute of Experimental and Clinical Research (IREC/LTAP), Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Jean-Cyr Yombi
- Division of Internal Medicine and Infectious Disease, Cliniques Universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Julien De Greef
- Division of Internal Medicine and Infectious Disease, Cliniques Universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Julien De Greef
- Louvain centre for Toxicology and Applied Pharmacology, Institute of Experimental and Clinical Research (IREC/LTAP), Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Olivier Cornu
- Department of Orthopedic and Trauma Surgery, Cliniques Universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Olivier Cornu
- Institute of Experimental and Clinical Research, Neuromusculoskeletal Lab (IREC/NMSK), Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Pierre-Louis Docquier
- Department of Orthopedic and Trauma Surgery, Cliniques Universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Pierre-Louis Docquier
- Institute of Experimental and Clinical Research, Neuromusculoskeletal Lab (IREC/NMSK), Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Audrey Lentini
- 0Departement of Plastic Surgery, Cliniques universitaires Saint-Luc, Université catholique de Louvain – UCLouvain, Brussels, Belgium
- Renaud Menten
- 1Department of Radiology, Pediatric Radiology Unit, Cliniques universitaires Saint-Luc, Université Catholique de Louvain – UCLouvain, Brussels, Belgium
- Hector Rodriguez-Villalobos
- 2Department of Microbiology, Cliniques universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Hector Rodriguez-Villalobos
- 3Institute of Experimental and Clinical Research, Medical Microbiology Department (IREC/MBLG), Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Alexia Verroken
- 2Department of Microbiology, Cliniques universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Alexia Verroken
- 3Institute of Experimental and Clinical Research, Medical Microbiology Department (IREC/MBLG), Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Sarah Djebara
- 4Center for Infectious Diseases, Queen Astrid Military Hospital, Brussels, Belgium
- Maya Merabishvili
- 5Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium
- Johann Griselain
- 5Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium
- Jean-Paul Pirnay
- 5Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium
- Laurent Houtekie
- Pediatric Intensive Care Unit, Cliniques universitaires Saint-Luc, Université catholique de Louvain – UCLouvain, Brussels, Belgium
- Dimitri Van der Linden
- Institute of Experimental and Clinical Research, Pediatric Department (IREC/PEDI), Université catholique de Louvain - UCLouvain, Brussels, Belgium
- Dimitri Van der Linden
- Pediatric Infectious Diseases, General Pediatrics Department, Cliniques universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium
- DOI
- https://doi.org/10.3389/fcimb.2024.1354681
- Journal volume & issue
-
Vol. 14
Abstract
Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant Staphylococcus aureus (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against Staphylococcus aureus, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, eventually leading to full recovery with no reported adverse events.
Keywords
- MRSA
- Panton and Valentine leukocidin (PVL)
- bacteriophage
- phage therapy
- necrotizing fasciitis
- pediatric intensive care unit
