Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis

Xin Guan; Liping Sun; Yuting Shen; Fengshan Jin; Xiaowan Bo; Chunyan Zhu; Xiaoxia Han; Xiaolong Li; Yu Chen; Huixiong Xu; Wenwen Yue

doi:10.1038/s41467-022-30543-w

Nature Communications (May 2022)

Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis

Xin Guan,
Liping Sun,
Yuting Shen,
Fengshan Jin,
Xiaowan Bo,
Chunyan Zhu,
Xiaoxia Han,
Xiaolong Li,
Yu Chen,
Huixiong Xu,
Wenwen Yue

Affiliations

Xin Guan: Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Liping Sun: Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Yuting Shen: Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Fengshan Jin: Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Xiaowan Bo: Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Chunyan Zhu: Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Xiaoxia Han: Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Xiaolong Li: Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Yu Chen: Materdicine Lab, School of Life Sciences, Shanghai University
Huixiong Xu: Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Wenwen Yue: Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University

DOI: https://doi.org/10.1038/s41467-022-30543-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Tumor recurrence after surgical resection is associated with a poor clinical outcome. Here the authors design a manganese dioxide-based nanosystem to increase response to radio-immunotherapy by relieving tumor hypoxia and targeting myeloid cells, showing reduced post-surgical cancer recurrence and metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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