ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis

Abstract

Abstract Objectives To screen and verify differential genes affecting the prognosis of breast cancer. Methods Breast cancer gene expression datasets were downloaded from the GEO database, and original data were analyzed in R. The TIMER database was used to analyze the relationship between ANLN and UBE2T and immune cell infiltration. Results Ten hub-key genes were identified, and survival analysis showed that UBE2T and ANLN were upregulated in breast cancer and their upregulation was associated with a poor prognosis. ANLN and UBE2T upregulation was associated with the prevalence of Th1 and Th2 cells, shifting the Th1/Th2 balance to Th2 in Basal and Luminal-B breast cancers, which indicates a poor prognosis (P < 0.05). Conclusion ANLN and UBE2T are potential biomarkers for predicting the prognosis of breast cancer.

Keywords

• Breast cancer
• Luminal type of breast cancer
• Prognostic biomarkers
• Immune regulation
• T cells