Communications Biology (Apr 2022)
A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling
- Julian A. Schreiber,
- Melina Möller,
- Mark Zaydman,
- Lu Zhao,
- Zachary Beller,
- Sebastian Becker,
- Nadine Ritter,
- Panpan Hou,
- Jingyi Shi,
- Jon Silva,
- Eva Wrobel,
- Nathalie Strutz-Seebohm,
- Niels Decher,
- Nicole Schmitt,
- Sven G. Meuth,
- Martina Düfer,
- Bernhard Wünsch,
- Jianmin Cui,
- Guiscard Seebohm
Affiliations
- Julian A. Schreiber
- Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster
- Melina Möller
- Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster
- Mark Zaydman
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University
- Lu Zhao
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University
- Zachary Beller
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University
- Sebastian Becker
- Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster
- Nadine Ritter
- Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster
- Panpan Hou
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University
- Jingyi Shi
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University
- Jon Silva
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University
- Eva Wrobel
- Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster
- Nathalie Strutz-Seebohm
- Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster
- Niels Decher
- Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg
- Nicole Schmitt
- Department of Biomedical Sciences, University of Copenhagen
- Sven G. Meuth
- Department of Neurology, University Hospital Düsseldorf
- Martina Düfer
- Institute of Pharmaceutical and Medicinal Chemistry, University of Münster
- Bernhard Wünsch
- Institute of Pharmaceutical and Medicinal Chemistry, University of Münster
- Jianmin Cui
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University
- Guiscard Seebohm
- Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster
- DOI
- https://doi.org/10.1038/s42003-022-03229-8
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
The binding site and mechanism of action for a benzodiazepine-derivative agonist on Kv7.1 channels is determined for drug development to treat long QT syndrome.
