A comparative study of Bee pollen, Silver sulfadiazin and Aloe vera cream on treatment of sulfur mustard induced skin injury in guinea pig

Abstract

The experimental study indicate that the internal and external gluthation are imprtant in cellular stability aginst sulphur mustared (SM) toxicity. The increase of external gluthation protects cells against SM and the decrease of internal gluthation dcreases cellular stability against SM toxicity. In present study the bee pollen cream (BPC) was tested against skin injury induced by SM due to its potential anti-inflammatory, antibacterial, wound healing, anti-oxidative and capillary strengthen activity that may affect the process of healing. The 20 μl of 10% sulfur mustard in isopropyl alcohol was dropped on shaved skin of guinea pig. The bee pollen (20%), silver sulfadiazine(1%), aloe vera cream and cream base was applied on the affected skin two times a day for 20 days and the area of injury was measured on 10, 25 and 30 days. The results indicate that the area of injury at 10, 25 and 30 days in the BPC treated group was significantly (P<0.05) lowered than compared to silver sulfadiazine, aloe vera cream and cream base treated groups.This positive result may need further experimental study using BPC having different percentage of active gredient as well as cream made up of mixture of alcoholic and water extraction of bee pollen testing for treatment of burn and SM inuced skin injury.

Keywords

• sulfur mustard
• bee pollen
• aloe vera
• skin injury