PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies

Molly A. Hall; John Wallace; Anastasia Lucas; Dokyoon Kim; Anna O. Basile; Shefali S. Verma; Cathy A. McCarty; Murray H. Brilliant; Peggy L. Peissig; Terrie E. Kitchner; Anurag Verma; Sarah A. Pendergrass; Scott M. Dudek; Jason H. Moore; Marylyn D. Ritchie

doi:10.1038/s41467-017-00802-2

Nature Communications (Oct 2017)

PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies

Molly A. Hall,
John Wallace,
Anastasia Lucas,
Dokyoon Kim,
Anna O. Basile,
Shefali S. Verma,
Cathy A. McCarty,
Murray H. Brilliant,
Peggy L. Peissig,
Terrie E. Kitchner,
Anurag Verma,
Sarah A. Pendergrass,
Scott M. Dudek,
Jason H. Moore,
Marylyn D. Ritchie

Affiliations

Molly A. Hall: Institute for Biomedical Informatics, Departments of Genetics and Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania
John Wallace: Biomedical and Translational Informatics Institute, Geisinger Health System
Anastasia Lucas: Biomedical and Translational Informatics Institute, Geisinger Health System
Dokyoon Kim: Biomedical and Translational Informatics Institute, Geisinger Health System
Anna O. Basile: Department of Biochemistry and Molecular Biology, Center for Systems Genomics, Eberly College of Science, The Pennsylvania State University
Shefali S. Verma: Biomedical and Translational Informatics Institute, Geisinger Health System
Cathy A. McCarty: Essentia Institute of Rural Health
Murray H. Brilliant: Marshfield Clinic Research Institute
Peggy L. Peissig: Marshfield Clinic Research Institute
Terrie E. Kitchner: Marshfield Clinic Research Institute
Anurag Verma: Biomedical and Translational Informatics Institute, Geisinger Health System
Sarah A. Pendergrass: Biomedical and Translational Informatics Institute, Geisinger Health System
Scott M. Dudek: Biomedical and Translational Informatics Institute, Geisinger Health System
Jason H. Moore: Institute for Biomedical Informatics, Departments of Genetics and Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania
Marylyn D. Ritchie: Biomedical and Translational Informatics Institute, Geisinger Health System

DOI: https://doi.org/10.1038/s41467-017-00802-2
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Centralized infrastructure to support analyses involving complexity beyond genome-wide association studies is broadly needed. Here, Ritchie and colleagues develop PLATO, a software tool to process and integrate various methods for this task.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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