Romanian Journal of Rheumatology (Sep 2018)

LUPUS NEPHRITIS AND PREGNANCY. THE RHEUMATOLOGIST’S OPINION

  • Alexandru Caraba,
  • Roxana Saulescu,
  • Viorica Crisan,
  • Denisa Predeteanu

DOI
https://doi.org/10.37897/RJR.2018.3.1
Journal volume & issue
Vol. 27, no. 3
pp. 99 – 107

Abstract

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In the presence of lupus nephritis, the pregnancy remains a challenging problem, requiring a multidisciplinary monitoring. Such pregnancies are considered as high risk similar to those with maternal and fetal potential complications. Thus, these pregnancies must be planned, after a multidisciplinary evaluation, performed by obstetrician, rheumatologist and nephrologist. Inactive disease for at least 6 months before conception, absence of hypertension, heavy proteinuria or important renal dysfunction are associated with good maternal-fetal outcomes. Lupus nephritis flare and preeclampsia may occur, associating a poor prognosis. Therapeutic regimens must be adapted, taking into account the teratogenic effects of the drugs.

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