Nature Communications (May 2020)
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy
- James P. Pirruccello,
- Alexander Bick,
- Minxian Wang,
- Mark Chaffin,
- Samuel Friedman,
- Jie Yao,
- Xiuqing Guo,
- Bharath Ambale Venkatesh,
- Kent D. Taylor,
- Wendy S. Post,
- Stephen Rich,
- Joao A. C. Lima,
- Jerome I. Rotter,
- Anthony Philippakis,
- Steven A. Lubitz,
- Patrick T. Ellinor,
- Amit V. Khera,
- Sekar Kathiresan,
- Krishna G. Aragam
Affiliations
- James P. Pirruccello
- Division of Cardiology, Massachusetts General Hospital
- Alexander Bick
- Center for Genomic Medicine, Massachusetts General Hospital
- Minxian Wang
- Program in Medical and Population Genetics, Broad Institute
- Mark Chaffin
- Program in Medical and Population Genetics, Broad Institute
- Samuel Friedman
- Data Sciences Platform, Broad Institute
- Jie Yao
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Xiuqing Guo
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Bharath Ambale Venkatesh
- Department of Radiology, Johns Hopkins University
- Kent D. Taylor
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Wendy S. Post
- Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health
- Stephen Rich
- Center for Public Health Genomics, University of Virginia
- Joao A. C. Lima
- Department of Radiology, Johns Hopkins University
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Anthony Philippakis
- Data Sciences Platform, Broad Institute
- Steven A. Lubitz
- Division of Cardiology, Massachusetts General Hospital
- Patrick T. Ellinor
- Division of Cardiology, Massachusetts General Hospital
- Amit V. Khera
- Division of Cardiology, Massachusetts General Hospital
- Sekar Kathiresan
- Division of Cardiology, Massachusetts General Hospital
- Krishna G. Aragam
- Division of Cardiology, Massachusetts General Hospital
- DOI
- https://doi.org/10.1038/s41467-020-15823-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
Structural changes to the left ventricle are characteristic of dilated cardiomyopathy (DCM), a disease for which many rare genetic variants are known. Here, Pirruccello et al. report GWAS of seven cardiac MRI measurements in the left ventricle and describe shared loci and polygenic association with DCM.
