A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specific Protective Antibodies

Ahmet Ozdilek; Jiachen Huang; Rachelle Babb; Amy V. Paschall; Dustin R. Middleton; Jeremy A. Duke; Liise-anne Pirofski; Jarrod J. Mousa; Fikri Y. Avci

doi:10.1128/mBio.00800-21

mBio (Jun 2021)

A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specific Protective Antibodies

Ahmet Ozdilek,
Jiachen Huang,
Rachelle Babb,
Amy V. Paschall,
Dustin R. Middleton,
Jeremy A. Duke,
Liise-anne Pirofski,
Jarrod J. Mousa,
Fikri Y. Avci

Affiliations

Ahmet Ozdilek: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Jiachen Huang: Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
Rachelle Babb: Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
Amy V. Paschall: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Dustin R. Middleton: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Jeremy A. Duke: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Liise-anne Pirofski: Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
Jarrod J. Mousa: ORCiD; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
Fikri Y. Avci: ORCiD; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA

DOI: https://doi.org/10.1128/mBio.00800-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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Infectious diseases caused by pathogenic bacteria are a major threat to human health. Capsular polysaccharides (CPSs) of many pathogenic bacteria have been used as the main components of glycoconjugate vaccines against bacterial diseases in clinical practice worldwide, with various degrees of success.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal