Bacteriological and Immunological study of kidney failure patients infected with urinary tract infections

Abstract

Urinary tract infections (UTIs) are one of the most common medical conditions in women and men. They are caused by bacteria that enter the urinary tract through the urethra or the skin around the genitals. In this study, 102 urine samples were collected from 74 patients infected UTIs and 28 patients infected with urinary tract infections with kidney failure (UTIs-KF) admitted to a general hospital in AL-Najaf City, Iraq, between October to 2022 and March 2023 and 30 healthy individuals as control group. Standard laboratory methods were used to culture urine and to diagnose all bacterial isolates that were grown on laboratory media. The levels of cytokines IL-6 and IL-33 were detected by ELISA technique in the serum of control and patients. The results proved that age group 41-50 years old was the most UTIs infected with 31 patients (30.3%) followed by the age group ≤51 with 25 patients (24.5%). Out of total of 102 urine samples, there were 106 bacterial isolates, E.coli was the most dominate bacteria with 50 isolates (47%) followed by K.pneumoniae 18 isolates (17%), P.mirabilis 13 (12.7%), S.saprophyticus 10(9.5%), S.aureus 9(8.5%) and E.faecalis 6(6%). IL-6 and IL-33 were significantly higher in the UTIs and UTIs-KF patients, compared with the control group.

Keywords

• bacterial infections
• kidney failure
• il-6
• il-33