Translational Psychiatry (Feb 2022)
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
- Cees J. Weeland,
- Selina Kasprzak,
- Niels T. de Joode,
- Yoshinari Abe,
- Pino Alonso,
- Stephanie H. Ameis,
- Alan Anticevic,
- Paul D. Arnold,
- Srinivas Balachander,
- Nerisa Banaj,
- Nuria Bargallo,
- Marcelo C. Batistuzzo,
- Francesco Benedetti,
- Jan C. Beucke,
- Irene Bollettini,
- Vilde Brecke,
- Silvia Brem,
- Carolina Cappi,
- Yuqi Cheng,
- Kang Ik K. Cho,
- Daniel L. C. Costa,
- Sara Dallaspezia,
- Damiaan Denys,
- Goi Khia Eng,
- Sónia Ferreira,
- Jamie D. Feusner,
- Martine Fontaine,
- Jean-Paul Fouche,
- Rachael G. Grazioplene,
- Patricia Gruner,
- Mengxin He,
- Yoshiyuki Hirano,
- Marcelo Q. Hoexter,
- Chaim Huyser,
- Hao Hu,
- Fern Jaspers-Fayer,
- Norbert Kathmann,
- Christian Kaufmann,
- Minah Kim,
- Kathrin Koch,
- Yoo Bin Kwak,
- Jun Soo Kwon,
- Luisa Lazaro,
- Chiang-shan R. Li,
- Christine Lochner,
- Rachel Marsh,
- Ignacio Martínez-Zalacaín,
- David Mataix-Cols,
- Jose M. Menchón,
- Luciano Minnuzi,
- Pedro Silva Moreira,
- Pedro Morgado,
- Akiko Nakagawa,
- Takashi Nakamae,
- Janardhanan C. Narayanaswamy,
- Erika L. Nurmi,
- Ana E. Ortiz,
- Jose C. Pariente,
- John Piacentini,
- Maria Picó-Pérez,
- Fabrizio Piras,
- Federica Piras,
- Christopher Pittenger,
- Y. C. Janardhan Reddy,
- Daniela Rodriguez-Manrique,
- Yuki Sakai,
- Eiji Shimizu,
- Venkataram Shivakumar,
- Helen Blair Simpson,
- Noam Soreni,
- Carles Soriano-Mas,
- Nuno Sousa,
- Gianfranco Spalletta,
- Emily R. Stern,
- Michael C. Stevens,
- S. Evelyn Stewart,
- Philip R. Szeszko,
- Jumpei Takahashi,
- Tais Tanamatis,
- Jinsong Tang,
- Anders Lillevik Thorsen,
- David Tolin,
- Ysbrand D. van der Werf,
- Hein van Marle,
- Guido A. van Wingen,
- Daniela Vecchio,
- G. Venkatasubramanian,
- Susanne Walitza,
- Jicai Wang,
- Zhen Wang,
- Anri Watanabe,
- Lidewij H. Wolters,
- Xiufeng Xu,
- Je-Yeon Yun,
- Qing Zhao,
- ENIGMA OCD Working Group,
- Tonya White,
- Paul M. Thompson,
- Dan J. Stein,
- Odile A. van den Heuvel,
- Chris Vriend
Affiliations
- Cees J. Weeland
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences
- Selina Kasprzak
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences
- Niels T. de Joode
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences
- Yoshinari Abe
- Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
- Pino Alonso
- Bellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital
- Stephanie H. Ameis
- Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
- Alan Anticevic
- Departments of Psychiatry and Neuroscience, Yale University
- Paul D. Arnold
- The Mathison Centre for Mental Health Research & Education, Departments of Psychiatry and Medical Genetics
- Srinivas Balachander
- OCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS)
- Nerisa Banaj
- Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation
- Nuria Bargallo
- Magnetic Resonance Image Core Facility, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS)
- Marcelo C. Batistuzzo
- Departamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
- Francesco Benedetti
- Vita-Salute San Raffaele University
- Jan C. Beucke
- Department of Psychology, Humboldt-Universität zu Berlin
- Irene Bollettini
- Psychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele
- Vilde Brecke
- Bergen Center for Brain Plasticity, Haukeland University Hospital
- Silvia Brem
- Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich
- Carolina Cappi
- Icahn School of Medicine at Mount Sinai Department of Psychiatry
- Yuqi Cheng
- Department of Psychiatry, First Affiliated Hospital of Kunming Medical University
- Kang Ik K. Cho
- Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Daniel L. C. Costa
- Obsessive-Compulsive Spectrum Disorders Program, Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP)
- Sara Dallaspezia
- IRCCS Ospedale San Raffaele, Milano Italy Psychiatry
- Damiaan Denys
- Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience
- Goi Khia Eng
- Department of Psychiatry, New York University School of Medicine
- Sónia Ferreira
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Jamie D. Feusner
- Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto
- Martine Fontaine
- Columbia University Medical College, Columbia University
- Jean-Paul Fouche
- Department of Psychiatry and Mental Health, University of Cape Town
- Rachael G. Grazioplene
- Department of Psychiatry, Yale University
- Patricia Gruner
- Department of Psychiatry, Yale University
- Mengxin He
- Department of Psychiatry, First Affiliated Hospital of Kunming Medical University
- Yoshiyuki Hirano
- Research Center for Child Mental Development, Chiba University
- Marcelo Q. Hoexter
- Departamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
- Chaim Huyser
- Levvel, Academic Center for Child and Adolescent Psychiatry
- Hao Hu
- Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Fern Jaspers-Fayer
- Department of Psychiatry, University of British Columbia
- Norbert Kathmann
- Department of Psychology, Humboldt-Universität zu Berlin
- Christian Kaufmann
- Department of Psychology, Humboldt-Universität zu Berlin
- Minah Kim
- Seoul National University Hospital, Department of Neuropsychiatry
- Kathrin Koch
- Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität
- Yoo Bin Kwak
- Department of Brain and Cognitive Sciences, Seoul National University College of Natural Science
- Jun Soo Kwon
- Department of Brain and Cognitive Sciences, Seoul National University College of Natural Science
- Luisa Lazaro
- Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic, IDIBAPS
- Chiang-shan R. Li
- CIBERSAM
- Christine Lochner
- Stellenbosch University, SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry
- Rachel Marsh
- Columbia University Medical College, Columbia University
- Ignacio Martínez-Zalacaín
- Bellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital
- David Mataix-Cols
- Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet
- Jose M. Menchón
- Bellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital
- Luciano Minnuzi
- Department of Psychiatry and Behavioral Neurosciences, McMaster University
- Pedro Silva Moreira
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Pedro Morgado
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Akiko Nakagawa
- Research Center for Child Mental Development, Chiba University
- Takashi Nakamae
- Graduate School of Medical Science Kyoto Prefectural University of Medicine, Department of Psychiatry
- Janardhanan C. Narayanaswamy
- OCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS)
- Erika L. Nurmi
- Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles
- Ana E. Ortiz
- Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic
- Jose C. Pariente
- Magnetic Resonance Image Core Facility, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS)
- John Piacentini
- UCLA Semel Institute, Division of Child and Adolescent Psychiatry
- Maria Picó-Pérez
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Fabrizio Piras
- Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation
- Federica Piras
- Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation
- Christopher Pittenger
- Department of Psychiatry and Yale Child Study Center, Yale University
- Y. C. Janardhan Reddy
- OCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS)
- Daniela Rodriguez-Manrique
- TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München
- Yuki Sakai
- Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
- Eiji Shimizu
- Research Center for Child Mental Development, Chiba University
- Venkataram Shivakumar
- Department of Integrative Medicine, National Institute of Mental Health and Neurosciences (NIMHANS)
- Helen Blair Simpson
- Columbia University Irving Medical College, Columbia University
- Noam Soreni
- Department of Psychiatry and Behavioral Neurosciences, McMaster University
- Carles Soriano-Mas
- Bellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital
- Nuno Sousa
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Gianfranco Spalletta
- IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry
- Emily R. Stern
- Department of Psychiatry, New York University School of Medicine
- Michael C. Stevens
- Institute of Living
- S. Evelyn Stewart
- Department of Psychiatry, University of British Columbia
- Philip R. Szeszko
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Jumpei Takahashi
- Department of Child Psychiatry, Chiba University Hospital
- Tais Tanamatis
- Departamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
- Jinsong Tang
- Department of Psychiatry, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University
- Anders Lillevik Thorsen
- Bergen Center for Brain Plasticity, Haukeland University Hospital
- David Tolin
- Yale University School of Medicine
- Ysbrand D. van der Werf
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences
- Hein van Marle
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences
- Guido A. van Wingen
- Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience
- Daniela Vecchio
- Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation
- G. Venkatasubramanian
- National Institute of Mental Health And Neurosciences, Department of Psychiatry
- Susanne Walitza
- Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich
- Jicai Wang
- Department of Psychiatry, First Affiliated Hospital of Kunming Medical University
- Zhen Wang
- Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Anri Watanabe
- Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
- Lidewij H. Wolters
- Amsterdam UMC, Department of Child and Adolescent Psychiatry
- Xiufeng Xu
- Department of Psychiatry, First Affiliated Hospital of Kunming Medical University
- Je-Yeon Yun
- Seoul National University Hospital
- Qing Zhao
- Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- ENIGMA OCD Working Group
- Tonya White
- Erasmus Medical Center, Department of Child and Adolescent Psychiatry/Psychology
- Paul M. Thompson
- Imaging Genetics Center, Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California
- Dan J. Stein
- SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town
- Odile A. van den Heuvel
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences
- Chris Vriend
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences
- DOI
- https://doi.org/10.1038/s41398-022-01823-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Abstract Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered ( https://osf.io/73dvy ) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p-values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = −0.15 to −0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.
