Nature Communications (Jul 2020)
Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
- Julie Sellau,
- Marie Groneberg,
- Helena Fehling,
- Thorsten Thye,
- Stefan Hoenow,
- Claudia Marggraff,
- Marie Weskamm,
- Charlotte Hansen,
- Stephanie Stanelle-Bertram,
- Svenja Kuehl,
- Jill Noll,
- Vincent Wolf,
- Nahla Galal Metwally,
- Sven Hendrik Hagen,
- Christoph Dorn,
- Julia Wernecke,
- Harald Ittrich,
- Egbert Tannich,
- Thomas Jacobs,
- Iris Bruchhaus,
- Marcus Altfeld,
- Hannelore Lotter
Affiliations
- Julie Sellau
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Marie Groneberg
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Helena Fehling
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Thorsten Thye
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Stefan Hoenow
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Claudia Marggraff
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Marie Weskamm
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Charlotte Hansen
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Stephanie Stanelle-Bertram
- Department Viral Zoonoses - One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology
- Svenja Kuehl
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Jill Noll
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Vincent Wolf
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Nahla Galal Metwally
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Sven Hendrik Hagen
- Research Department Virus Immunology, Heinrich Pette Institute
- Christoph Dorn
- Amedes Experts
- Julia Wernecke
- Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf
- Harald Ittrich
- Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf
- Egbert Tannich
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Thomas Jacobs
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Iris Bruchhaus
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- Marcus Altfeld
- Research Department Virus Immunology, Heinrich Pette Institute
- Hannelore Lotter
- Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine
- DOI
- https://doi.org/10.1038/s41467-020-17260-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Altered monocyte responses and testosterone levels correlate, individually, with the pathogenesis of hepatic amebiasis in mice. Here the authors show that testosterone induces enhanced TNF/CXCL1 expression and stronger proinflammatory responses in both human and mouse monocytes to support an androgen-monocyte axis of inflammation regulation.
