Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry (Jun 2024)

Green and Efficient Synthesis of Dihydropyrimidinone Analogues via Hpa-Clay Catalyzed Biginelli Reaction

  • Nuzhat Rehman,
  • Ayaz Mahmood Dar,
  • Raja Feroz Ahmad Haji,
  • Sharief-ud-din Khan,
  • Deepak Pareek,
  • Saleem Farooq,
  • Bashir Ahmad Dar

DOI
https://doi.org/10.19261/cjm.2024.1135
Journal volume & issue
Vol. 19, no. 1
pp. 76 – 83

Abstract

Read online

This study introduces an environmentally sustainable approach for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs), via the Biginelli reaction. A heterogeneous catalyst, Heteropolyacid-Clay (HPA-Clay), is developed by immobilizing H5PV2W10O40 on Montmorillonite KSF clay. The catalyst exhibits enhanced stability and catalytic efficiency, confirmed through X-ray powder diffraction and scanning electron microscopy. Utilizing a one-pot multi-component strategy under solvent-free conditions, various aldehydes, urea or thiourea, and ethylacetoacetate generate DHPMs with excellent yields and reduced reaction times. Catalysed by 2 mol% HPA-Clay, the process aligns with green chemistry principles, emphasizing cost-efficiency, environmental sustainability, and recyclability. The catalyst demonstrates consistent activity over multiple cycles, highlighting its potential for advancing Biginelli reactions.

Keywords