Communications Biology (Jan 2023)
Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21
- Jun Muto,
- Shinji Fukuda,
- Kenji Watanabe,
- Xiuju Dai,
- Teruko Tsuda,
- Takeshi Kiyoi,
- Kenji Kameda,
- Ryosuke Kawakami,
- Hideki Mori,
- Ken Shiraishi,
- Masamoto Murakami,
- Takeshi Imamura,
- Shigeki Higashiyama,
- Yasuhiro Fujisawa,
- Yoichi Mizukami,
- Koji Sayama
Affiliations
- Jun Muto
- Department of Dermatology, Ehime University Graduate School of Medicine
- Shinji Fukuda
- Department of Biochemistry, School of Dentistry, Aichi Gakuin University
- Kenji Watanabe
- Institute of Gene Research, Yamaguchi University Science Research Center
- Xiuju Dai
- Department of Dermatology, Ehime University Graduate School of Medicine
- Teruko Tsuda
- Department of Dermatology, Ehime University Graduate School of Medicine
- Takeshi Kiyoi
- Department of Pharmacology, School of Medicine, Kanazawa Medical University
- Kenji Kameda
- Department of Dermatology, Ehime University Graduate School of Medicine
- Ryosuke Kawakami
- Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine
- Hideki Mori
- Department of Dermatology, Ehime University Graduate School of Medicine
- Ken Shiraishi
- Department of Dermatology, Ehime University Graduate School of Medicine
- Masamoto Murakami
- Department of Dermatology, Ehime University Graduate School of Medicine
- Takeshi Imamura
- Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine
- Shigeki Higashiyama
- Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University
- Yasuhiro Fujisawa
- Department of Dermatology, Ehime University Graduate School of Medicine
- Yoichi Mizukami
- Institute of Gene Research, Yamaguchi University Science Research Center
- Koji Sayama
- Department of Dermatology, Ehime University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s42003-022-04408-3
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 18
Abstract
Highly concentrated trehalose induces beneficial senescence-like state in fibroblasts and accelerates the proliferation of keratinocytes and angiogenesis to promote optimal wound repair, demonstrating its therapeutic potential in modulating fibroblast functions.
