Spherical particles derived from TMV virions enhance the protective properties of the rabies vaccine

N.A. Nikitin; I.N. Matveeva; E.A. Trifonova; N.M. Puhova; A. Ya Samuylenko; S.A. Gryn; J.G. Atabekov; O.V. Karpova

Data in Brief (Dec 2018)

Spherical particles derived from TMV virions enhance the protective properties of the rabies vaccine

N.A. Nikitin,
I.N. Matveeva,
E.A. Trifonova,
N.M. Puhova,
A. Ya Samuylenko,
S.A. Gryn,
J.G. Atabekov,
O.V. Karpova

Affiliations

N.A. Nikitin: Department of Virology, Lomonosov Moscow State University, 1/12 Leninskie gory, Moscow 119234, Russia; Corresponding author.
I.N. Matveeva: All-Russian Scientific Research and Technological Institute of Biological Industry, VNITIBP 17, Moscow region, Shchelkovsky district 141142, Russia
E.A. Trifonova: Department of Virology, Lomonosov Moscow State University, 1/12 Leninskie gory, Moscow 119234, Russia
N.M. Puhova: All-Russian Scientific Research and Technological Institute of Biological Industry, VNITIBP 17, Moscow region, Shchelkovsky district 141142, Russia
A. Ya Samuylenko: All-Russian Scientific Research and Technological Institute of Biological Industry, VNITIBP 17, Moscow region, Shchelkovsky district 141142, Russia
S.A. Gryn: All-Russian Scientific Research and Technological Institute of Biological Industry, VNITIBP 17, Moscow region, Shchelkovsky district 141142, Russia
J.G. Atabekov: Department of Virology, Lomonosov Moscow State University, 1/12 Leninskie gory, Moscow 119234, Russia
O.V. Karpova: Department of Virology, Lomonosov Moscow State University, 1/12 Leninskie gory, Moscow 119234, Russia

Journal volume & issue: Vol. 21
pp. 742 – 745

Abstract

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In this study the ability of spherical particles (SPs) obtained from the tobacco mosaic virus (TMV) virions to enhance the immunogenic potential of the vaccine was evaluated. TMV SPs were shown to increase the protective properties of the widely used effective Russian adjuvant-free rabies vaccine, composed of killed rabies virions. The results of the NIH potency test showed enhancement of protectivity, that is comparable with the effect of the incomplete Freund׳s adjuvant on the same vaccine. Keywords: Rabies vaccine, Plant virus, Spherical particles, Adjuvant

Published in Data in Brief

ISSN: 2352-3409 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Science (General)
Website: http://www.journals.elsevier.com/data-in-brief/

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