Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

Angela E. M. Ibler; Mohamed ElGhazaly; Kathryn L. Naylor; Natalia A. Bulgakova; Sherif F. El-Khamisy; Daniel Humphreys

doi:10.1038/s41467-019-12064-1

Nature Communications (Sep 2019)

Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

Angela E. M. Ibler,
Mohamed ElGhazaly,
Kathryn L. Naylor,
Natalia A. Bulgakova,
Sherif F. El-Khamisy,
Daniel Humphreys

Affiliations

Angela E. M. Ibler: Department of Biomedical Science, University of Sheffield
Mohamed ElGhazaly: Department of Biomedical Science, University of Sheffield
Kathryn L. Naylor: Department of Biomedical Science, University of Sheffield
Natalia A. Bulgakova: Department of Biomedical Science, University of Sheffield
Sherif F. El-Khamisy: The Healthy Life Span Institute, Department of Molecular Biology and Biotechnology, University of Sheffield
Daniel Humphreys: Department of Biomedical Science, University of Sheffield

DOI: https://doi.org/10.1038/s41467-019-12064-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Salmonella Typhi produces the typhoid toxin, which damages host cell DNA. Here, Ibler et al. show that the toxin induces a non-canonical DNA damage response mediated by the RPA pathway that drives host cell senescence and facilitates infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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