Nature Communications (Dec 2017)
Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility
- Amit Sud,
- Hauke Thomsen,
- Philip J. Law,
- Asta Försti,
- Miguel Inacio da Silva Filho,
- Amy Holroyd,
- Peter Broderick,
- Giulia Orlando,
- Oleg Lenive,
- Lauren Wright,
- Rosie Cooke,
- Douglas Easton,
- Paul Pharoah,
- Alison Dunning,
- Julian Peto,
- Federico Canzian,
- Rosalind Eeles,
- ZSofia Kote-Jarai,
- Kenneth Muir,
- Nora Pashayan,
- The PRACTICAL consortium,
- Per Hoffmann,
- Markus M. Nöthen,
- Karl-Heinz Jöckel,
- Elke Pogge von Strandmann,
- Tracy Lightfoot,
- Eleanor Kane,
- Eve Roman,
- Annette Lake,
- Dorothy Montgomery,
- Ruth F. Jarrett,
- Anthony J. Swerdlow,
- Andreas Engert,
- Nick Orr,
- Kari Hemminki,
- Richard S. Houlston
Affiliations
- Amit Sud
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Hauke Thomsen
- Division of Molecular Genetic Epidemiology, German Cancer Research Centre
- Philip J. Law
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Asta Försti
- Division of Molecular Genetic Epidemiology, German Cancer Research Centre
- Miguel Inacio da Silva Filho
- Division of Molecular Genetic Epidemiology, German Cancer Research Centre
- Amy Holroyd
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Peter Broderick
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Giulia Orlando
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Oleg Lenive
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Lauren Wright
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Rosie Cooke
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Douglas Easton
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Paul Pharoah
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Alison Dunning
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Julian Peto
- Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine
- Federico Canzian
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- Rosalind Eeles
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- ZSofia Kote-Jarai
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Kenneth Muir
- Institute of Population Health, University of Manchester
- Nora Pashayan
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- The PRACTICAL consortium
- Per Hoffmann
- Department of Biomedicine, Division of Medical Genetics, University of Basel
- Markus M. Nöthen
- Institute of Human Genetics, University of Bonn
- Karl-Heinz Jöckel
- University of Duisburg–Essen
- Elke Pogge von Strandmann
- Department of Internal Medicine, University Hospital of Cologne
- Tracy Lightfoot
- Department of Health Sciences, University of York
- Eleanor Kane
- Department of Health Sciences, University of York
- Eve Roman
- Department of Health Sciences, University of York
- Annette Lake
- MRC University of Glasgow Centre for Virus Research
- Dorothy Montgomery
- MRC University of Glasgow Centre for Virus Research
- Ruth F. Jarrett
- MRC University of Glasgow Centre for Virus Research
- Anthony J. Swerdlow
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Andreas Engert
- Department of Internal Medicine, University Hospital of Cologne
- Nick Orr
- Division of Molecular Pathology, The Institute of Cancer Research
- Kari Hemminki
- Division of Molecular Genetic Epidemiology, German Cancer Research Centre
- Richard S. Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- DOI
- https://doi.org/10.1038/s41467-017-00320-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Classical Hodgkin lymphoma is a cancer that originates in lymph nodes. Little is known about its genetic susceptibility. Here, the authors combined existing and new genome-wide association studies to identify risk loci for classical Hodgkin lymphoma at 6q22.33, and nodular sclerosis Hodgkin lymphoma at 3q28, 6q23.3, 10p14, 13q34, 16p13.13.
