Nature Communications (May 2021)

Genome information processing by the INO80 chromatin remodeler positions nucleosomes

  • Elisa Oberbeckmann,
  • Nils Krietenstein,
  • Vanessa Niebauer,
  • Yingfei Wang,
  • Kevin Schall,
  • Manuela Moldt,
  • Tobias Straub,
  • Remo Rohs,
  • Karl-Peter Hopfner,
  • Philipp Korber,
  • Sebastian Eustermann

DOI
https://doi.org/10.1038/s41467-021-23016-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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DNA sequence preferences or statistical positioning of histones has not explained genomic patterns of nucleosome organisation in vivo. Here, the authors establish DNA shape/mechanics as key elements that have evolved together with binding sites of DNA sequence-specific barriers so that such information directs nucleosome positioning by chromatin remodelers.