Respiratory Medicine Case Reports (Jan 2014)

Two patients with new granulomatous lung lesions during treatment of Crohn's disease

  • Satoshi Takeda,
  • Takanori Akagi,
  • Hiroyuki Miyazaki,
  • Masaru Kodama,
  • Satoshi Yamamoto,
  • Takahiro Beppu,
  • Takashi Nagahama,
  • Toshiyuki Matsui,
  • Kentaro Watanabe,
  • Nobuhiko Nagata

DOI
https://doi.org/10.1016/j.rmcr.2014.02.002
Journal volume & issue
Vol. 12, no. C
pp. 16 – 18

Abstract

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Two patients with granulomatous lung lesions thought to be related to Crohn's disease (CD) are reported. Patient 1 was a 43-year-old man who was diagnosed with CD at age 11 years. He developed a fever in the 38 °C, and a chest X-ray and CT scan showed infiltrates with air bronchograms in the right upper lobe and left lingular segment. Transbronchial lung biopsy (TBLB) revealed granulomatous lesions. Patient 2 was a 76-year-old woman who was diagnosed with CD at age 44 years. Chest CT showed infiltrates and nodular shadows in both lung fields. Video-assisted thoracoscopic surgery (VATS) in June 2012 revealed granulomatous lesions. Tuberculosis, fungal infections, drug-induced lung disorder, and sarcoidosis were ruled out as a cause of the granulomatous lesions in both patients. The aetiology was thought to be CD.

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