Nature Communications (Oct 2018)
Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
- Cuijun Zhang,
- Xuan Du,
- Kai Tang,
- Zhenlin Yang,
- Li Pan,
- Peipei Zhu,
- Jinyan Luo,
- Yuwei Jiang,
- Hui Zhang,
- Huafang Wan,
- Xingang Wang,
- Fengkai Wu,
- W. Andy Tao,
- Xin-Jian He,
- Heng Zhang,
- Ray A. Bressan,
- Jiamu Du,
- Jian-Kang Zhu
Affiliations
- Cuijun Zhang
- National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Xuan Du
- National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Kai Tang
- National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Zhenlin Yang
- National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Li Pan
- Department of Biochemistry, Purdue University
- Peipei Zhu
- Department of Biochemistry, Purdue University
- Jinyan Luo
- National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Yuwei Jiang
- National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Hui Zhang
- National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Huafang Wan
- Department of Horticulture and Landscape Architecture, Purdue University
- Xingang Wang
- Department of Horticulture and Landscape Architecture, Purdue University
- Fengkai Wu
- Department of Horticulture and Landscape Architecture, Purdue University
- W. Andy Tao
- Department of Biochemistry, Purdue University
- Xin-Jian He
- National Institute of Biological Sciences
- Heng Zhang
- National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Ray A. Bressan
- Department of Horticulture and Landscape Architecture, Purdue University
- Jiamu Du
- National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Jian-Kang Zhu
- National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-018-06965-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
DNA methylation and H3K9 dimethylation are two linked epigenetic marks of silenced chromatin in plants that depend on the activity of CMT3/2 and SUVH4/5/6. Here the authors identify AGDP1 as an H3K9me2-binding protein required for heterochromatic non-CG DNA methylation, H3K9 dimethylation, and transcriptional silencing.
