Bioactivity-Guided Fractionation and Identification of Antidiabetic Compound of <i>Syzygium polyanthum</i> (Wight.)’s Leaf Extract in Streptozotocin-Induced Diabetic Rat Model

Abstract

(1) Background: An earlier study on the hypoglycemic activity of S. polyanthum (Wight.) leaf methanol extract identified squalene as the major chemical compound. The present study was conducted to assess the hypoglycemic effect of fractions and subfractions of the methanol extract of S. polyanthum compared to the squalene using a bioassay-guided in vivo study. (2) Methods: The methanol extract was fractionated using the liquid–liquid fractionation method. Streptozotocin-induced type 1 diabetic rat was used to study the hypoglycemic effect. (3) Results: The findings showed that chloroform fraction significantly (p p S. polyanthum.

Keywords

• antihyperglycemic
• Indonesian bay leaves
• <i>Syzygium polyanthum</i> (Wight.)
• diabetes
• squalene