Nature Communications (Nov 2019)
Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence
- Kun Zhang,
- Yan Fang,
- Yaping He,
- Haohao Yin,
- Xin Guan,
- Yinying Pu,
- Bangguo Zhou,
- Wenwen Yue,
- Weiwei Ren,
- Dou Du,
- Hongyan Li,
- Chang Liu,
- Liping Sun,
- Yu Chen,
- Huixiong Xu
Affiliations
- Kun Zhang
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Yan Fang
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Yaping He
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Haohao Yin
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Xin Guan
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Yinying Pu
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Bangguo Zhou
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Wenwen Yue
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Weiwei Ren
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Dou Du
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Hongyan Li
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Chang Liu
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Liping Sun
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- Yu Chen
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences
- Huixiong Xu
- Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji University
- DOI
- https://doi.org/10.1038/s41467-019-13115-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
The efficacy of tumour starvation therapy is limited by lack of persistent tumour suppression, tumour metastasis and recurrence. Here, the authors report biocompatible gold nanorods and thermal-sensitive hydrogel to promote narrowing of blood vessels and show this to reduce tumour growth and metastasis.
