Reduced Steering Performance in Magnetic Drug Targeting Induced by Shielding Arising from Accumulation of Particles

Abstract

Magnetic Drug Targeting is a new approach in cancer therapy, where magnetic nanoparticles are used as carriers for cancer drugs. Commonly, external magnets are employed for steering the particles inside the blood vessels towards a desired direction. However, an unwanted side effect of the steering is the accumulation of the particles underneath the steering magnet. Many researchers address the number of accumulated particles, but, to the best of the authors’ knowledge, the retroaction of the accumulation profile on the generated magnetic field and, therefore, on the magnetic steering force, has not been investigated so far. Thus, in the proposed study, the influence of the accumulation profile on the magnetic force was numerically investigated. Therefore, a 2D model of a blood vessel with particles assumed as an accumulation profile and a nearby magnet was examined. Moreover, the length, thickness, and effective susceptibility of the approximated accumulation profile and the magnet size were varied. The results reveal that the field distribution is significantly affected, especially for high effective susceptibilities. The initially applied profile amplified the magnetic force; however, when the profile accumulated, it reduced the force up to 50 %. Overall, the results reveal that the retroaction of the particle distribution on the magnetic field must be considered in a simulation model.

Keywords

• magnetic drug targeting
• magnetic nanoparticles
• particle accumulation
• shielding
• steering