Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy

Bin Wang, MD, PhD; Ze-Mu Wang, MD, PhD; Jia-Ling Ji, MD; Weihua Gan, PhD; Aiqing Zhang, PhD; Hao-Jie Shi, MD; Hao Wang, PhD; Linli Lv, MD; Zuolin Li, MD; Taotao Tang, MD; Jie Du, PhD; Xiaonan H. Wang, MD; Bi-Cheng Liu, MD, PhD

JACC: Basic to Translational Science (Feb 2020)

Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy

Bin Wang, MD, PhD,
Ze-Mu Wang, MD, PhD,
Jia-Ling Ji, MD,
Weihua Gan, PhD,
Aiqing Zhang, PhD,
Hao-Jie Shi, MD,
Hao Wang, PhD,
Linli Lv, MD,
Zuolin Li, MD,
Taotao Tang, MD,
Jie Du, PhD,
Xiaonan H. Wang, MD,
Bi-Cheng Liu, MD, PhD

Affiliations

Bin Wang, MD, PhD: Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China
Ze-Mu Wang, MD, PhD: Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Jia-Ling Ji, MD: Department of Pediatric Nephrology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Weihua Gan, PhD: Department of Pediatric Nephrology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Aiqing Zhang, PhD: Department of Pediatric Nephrology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Hao-Jie Shi, MD: Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Hao Wang, PhD: Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Linli Lv, MD: Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China
Zuolin Li, MD: Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China
Taotao Tang, MD: Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China
Jie Du, PhD: Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Xiaonan H. Wang, MD: Department of Medicine, Renal Division, Emory University, Atlanta, Georgia
Bi-Cheng Liu, MD, PhD: Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China; Address for correspondence: Dr. Bi-Cheng Liu, Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine No. 87, Dingjiaqiao Road, Gulou District, Nanjing, Jiangsu Province, China.

Journal volume & issue: Vol. 5, no. 2
pp. 148 – 166

Abstract

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Summary: miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155–containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting FoxO3a in uremic mice. Key Words: exosome, FoxO3a, miR-155, pyroptosis, uremic cardiomyopathy

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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