Tailoring the elasticity of nerve implants for regulating peripheral nerve regeneration

Yan Kong; Jiawei Xu; Wenchao Guan; Shaolan Sun; Yumin Yang; Guicai Li

Smart Materials in Medicine (Jan 2023)

Tailoring the elasticity of nerve implants for regulating peripheral nerve regeneration

Yan Kong,
Jiawei Xu,
Wenchao Guan,
Shaolan Sun,
Yumin Yang,
Guicai Li

Affiliations

Yan Kong: Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Lab for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, 226001, Nantong, PR China
Jiawei Xu: Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Lab for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, 226001, Nantong, PR China
Wenchao Guan: Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Lab for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, 226001, Nantong, PR China
Shaolan Sun: Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Lab for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, 226001, Nantong, PR China
Yumin Yang: Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Lab for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, 226001, Nantong, PR China; Corresponding author.
Guicai Li: Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Lab for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, 226001, Nantong, PR China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, 610065, Chengdu, PR China; Corresponding author. Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Lab for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, 226001, Nantong, PR China.

Journal volume & issue: Vol. 4
pp. 266 – 285

Abstract

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Numerous studies have conducted in-depth research on the biological and chemical properties of tissue-engineered neural graft (TENG) on peripheral nerve regeneration, while the physical properties of the graft also display a significant impact on the regeneration of the injured nerve. Among them, the elasticity properties of TENG show a significant impact on the adhesion, proliferation, migration and bio-functionality of nerve cells in peripheral nerve regeneration. This review summarizes the latest research progress on elastic biomaterials for peripheral nervous system (PNS), including categories of elastic biomaterials, preparation methods and the effect of elasticity on the growth behavior of nerve cells, etc. In addition, the effect of the elastic substrate on the elasticity of the cell itself is also briefly described. Finally, we analyze and discuss the underlying mechanism by which elastic substrate affects nerve cell behavior.

Published in Smart Materials in Medicine

ISSN: 2590-1834 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology
Website: https://www.keaipublishing.com/en/journals/smart-materials-in-medicine/

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