Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner

Luis Zurkirchen; Sandra Varum; Sonja Giger; Annika Klug; Jessica Häusel; Raphaël Bossart; Martina Zemke; Claudio Cantù; Zeynep Kalender Atak; Nicola Zamboni; Konrad Basler; Lukas Sommer

doi:10.1038/s41467-019-09823-5

Nature Communications (May 2019)

Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner

Luis Zurkirchen,
Sandra Varum,
Sonja Giger,
Annika Klug,
Jessica Häusel,
Raphaël Bossart,
Martina Zemke,
Claudio Cantù,
Zeynep Kalender Atak,
Nicola Zamboni,
Konrad Basler,
Lukas Sommer

Affiliations

Luis Zurkirchen: Institute of Anatomy, University of Zurich
Sandra Varum: Institute of Anatomy, University of Zurich
Sonja Giger: Institute of Anatomy, University of Zurich
Annika Klug: Institute of Anatomy, University of Zurich
Jessica Häusel: Institute of Anatomy, University of Zurich
Raphaël Bossart: Institute of Anatomy, University of Zurich
Martina Zemke: Institute of Anatomy, University of Zurich
Claudio Cantù: Institute of Molecular Life Sciences, University of Zurich
Zeynep Kalender Atak: Laboratory of Computational Biology, KU Leuven Center for Human Genetics
Nicola Zamboni: Institute of Molecular Systems Biology, ETH Zurich
Konrad Basler: Institute of Molecular Life Sciences, University of Zurich
Lukas Sommer: Institute of Anatomy, University of Zurich

DOI: https://doi.org/10.1038/s41467-019-09823-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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The transcription factor Yin Yang 1 (YY1) plays an important role in human disease, yet little is known about its role in brain development. This study shows that YY1 controls cerebral cortex development by maintaining proliferation and survival of neural progenitor cells via transcriptional regulation of genes involved in metabolism and protein translation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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