A diencephalic circuit in rats for opioid analgesia but not positive reinforcement

Maggie W. Waung; Kayla A. Maanum; Thomas J. Cirino; Joseph R. Driscoll; Chris O’Brien; Svetlana Bryant; Kasra A. Mansourian; Marisela Morales; David J. Barker; Elyssa B. Margolis

doi:10.1038/s41467-022-28332-6

Nature Communications (Feb 2022)

A diencephalic circuit in rats for opioid analgesia but not positive reinforcement

Maggie W. Waung,
Kayla A. Maanum,
Thomas J. Cirino,
Joseph R. Driscoll,
Chris O’Brien,
Svetlana Bryant,
Kasra A. Mansourian,
Marisela Morales,
David J. Barker,
Elyssa B. Margolis

Affiliations

Maggie W. Waung: UCSF Weill Institute for Neurosciences, Department of Neurology, University of California
Kayla A. Maanum: UCSF Weill Institute for Neurosciences, Department of Neurology, University of California
Thomas J. Cirino: UCSF Weill Institute for Neurosciences, Department of Neurology, University of California
Joseph R. Driscoll: UCSF Weill Institute for Neurosciences, Department of Neurology, University of California
Chris O’Brien: Department of Psychology, Rutgers University
Svetlana Bryant: Department of Psychology, Rutgers University
Kasra A. Mansourian: UCSF Weill Institute for Neurosciences, Department of Neurology, University of California
Marisela Morales: National Institute on Drug Abuse, Neuronal Networks Section, National Institutes of Health
David J. Barker: Department of Psychology, Rutgers University
Elyssa B. Margolis: UCSF Weill Institute for Neurosciences, Department of Neurology, University of California

DOI: https://doi.org/10.1038/s41467-022-28332-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

Opioids are potent analgesics but also have addiction risk. Here a lateral preoptic area to lateral habenula connection is identified by which opioids relieve ongoing pain but do not produce reward in animals that do not have ongoing pain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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