Nature Communications (Aug 2022)
Derivation and utility of schizophrenia polygenic risk associated multimodal MRI frontotemporal network
- Shile Qi,
- Jing Sui,
- Godfrey Pearlson,
- Juan Bustillo,
- Nora I. Perrone-Bizzozero,
- Peter Kochunov,
- Jessica A. Turner,
- Zening Fu,
- Wei Shao,
- Rongtao Jiang,
- Xiao Yang,
- Jingyu Liu,
- Yuhui Du,
- Jiayu Chen,
- Daoqiang Zhang,
- Vince D. Calhoun
Affiliations
- Shile Qi
- College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics
- Jing Sui
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University
- Godfrey Pearlson
- Department of Psychiatry, Yale School of Medicine
- Juan Bustillo
- Departments of Psychiatry and Behavioral Sciences, University of New Mexico
- Nora I. Perrone-Bizzozero
- Departments of Psychiatry and Behavioral Sciences, University of New Mexico
- Peter Kochunov
- Department of Psychiatry, University of Maryland School of Medicine
- Jessica A. Turner
- Department of Psychology, Georgia State University
- Zening Fu
- Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), [Georgia State University, Georgia Institute of Technology, Emory University]
- Wei Shao
- College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics
- Rongtao Jiang
- Department of Radiology and Biomedical Imaging, Yale University
- Xiao Yang
- Huaxi Brain Research Center, West China Hospital of Sichuan University
- Jingyu Liu
- Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), [Georgia State University, Georgia Institute of Technology, Emory University]
- Yuhui Du
- School of Computer & Information Technology, Shanxi University
- Jiayu Chen
- Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), [Georgia State University, Georgia Institute of Technology, Emory University]
- Daoqiang Zhang
- College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics
- Vince D. Calhoun
- Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), [Georgia State University, Georgia Institute of Technology, Emory University]
- DOI
- https://doi.org/10.1038/s41467-022-32513-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Schizophrenia is highly heritable and characterized by widespread brain abnormalities. Here, the authors identify schizophrenia polygenic risk associated multimodal frontotemporal network that can serve as a transdiagnostic brain signature specific to schizophrenia.
