Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

Nilah M. Ioannidis; Wei Wang; Nicholas A. Furlotte; David A. Hinds; 23andMe Research Team; Carlos D. Bustamante; Eric Jorgenson; Maryam M. Asgari; Alice S. Whittemore

doi:10.1038/s41467-018-06149-6

Nature Communications (Oct 2018)

Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

Nilah M. Ioannidis,
Wei Wang,
Nicholas A. Furlotte,
David A. Hinds,
23andMe Research Team,
Carlos D. Bustamante,
Eric Jorgenson,
Maryam M. Asgari,
Alice S. Whittemore

Affiliations

Nilah M. Ioannidis: Department of Biomedical Data Science, Stanford University School of Medicine
Wei Wang: Department of Health Research and Policy, Stanford University School of Medicine
Nicholas A. Furlotte: 23andMe, Inc.
David A. Hinds: 23andMe, Inc.
23andMe Research Team: 23andMe, Inc.
Carlos D. Bustamante: Department of Biomedical Data Science, Stanford University School of Medicine
Eric Jorgenson: Division of Research, Kaiser Permanente Northern California
Maryam M. Asgari: Division of Research, Kaiser Permanente Northern California
Alice S. Whittemore: Department of Biomedical Data Science, Stanford University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-06149-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS). Here, the authors impute gene expression levels from GWAS data to perform a transcriptome wide association study (TWAS), identifying five novel genetic loci linked to cSCC susceptibility.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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