Cellular forces and matrix assembly coordinate fibrous tissue repair

Mahmut Selman Sakar; Jeroen Eyckmans; Roel Pieters; Daniel Eberli; Bradley J. Nelson; Christopher S. Chen

doi:10.1038/ncomms11036

Nature Communications (Mar 2016)

Cellular forces and matrix assembly coordinate fibrous tissue repair

Mahmut Selman Sakar,
Jeroen Eyckmans,
Roel Pieters,
Daniel Eberli,
Bradley J. Nelson,
Christopher S. Chen

Affiliations

Mahmut Selman Sakar: Institute of Robotics and Intelligent Systems, Eidgenössische Technische Hochschule Zürich
Jeroen Eyckmans: Department of Biomedical Engineering, Boston University
Roel Pieters: Institute of Robotics and Intelligent Systems, Eidgenössische Technische Hochschule Zürich
Daniel Eberli: Department of Urology, Laboratory for Urologic Tissue Engineering and Stem Cell Therapy, University Hospital
Bradley J. Nelson: Institute of Robotics and Intelligent Systems, Eidgenössische Technische Hochschule Zürich
Christopher S. Chen: Department of Biomedical Engineering, Boston University

DOI: https://doi.org/10.1038/ncomms11036
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

Read online

Planar in vitromodels for wound closure stress the role of lamellipodial protrusions and purse-string contraction. Here the authors develop a 3D biomimetic model for tissue repair and show a mode of stromal closure that relies on whole tissue deformations, cell migration and matrix deposition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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